慢性左旋多巴治疗的帕金森病患者的局部脑血流量：“开”和“关”反应波动期间的测量
Regional cerebral blood flow in patients with Parkinson's disease under chronic levodopa therapy: measurements during "on" and "off" response fluctuations.
作者信息
Melamed E, Globus M, Mildworf B
出版信息
J Neurol Neurosurg Psychiatry. 1986 Nov;49(11):1301-4. doi: 10.1136/jnnp.49.11.1301.
Abstract
In ten Parkinsonians who developed dose-related response fluctuations under long-term levodopa therapy, regional cerebral blood flow (rCBF) and plasma levodopa levels were measured simultaneously, once during an "off" phase and again at an "on" stage of clinical benefit induced by a single oral dose of levodopa. Although plasma levodopa increased threefold during the "on" period, rCBF and the degree of its reduction from normal age-matched control values remained unchanged and similar to those in the "off" phase. Study suggests that the rCBF decreases in Parkinson's disease are unaffected by levodopa and are not due to deficient dopaminergic neurotransmission in the brain.
摘要
在10名长期接受左旋多巴治疗出现剂量相关反应波动的帕金森病患者中，在“关”期和单次口服左旋多巴诱导的临床获益“开”期分别同时测量了局部脑血流量（rCBF）和血浆左旋多巴水平。尽管在“开”期血浆左旋多巴增加了两倍，但rCBF及其相对于年龄匹配正常对照值的降低程度保持不变，且与“关”期相似。研究表明，帕金森病中的rCBF降低不受左旋多巴影响，并非由于大脑中多巴胺能神经传递不足所致。
相似文献
1
Regional cerebral blood flow in patients with Parkinson's disease under chronic levodopa therapy: measurements during "on" and "off" response fluctuations.慢性左旋多巴治疗的帕金森病患者的局部脑血流量：“开”和“关”反应波动期间的测量
J Neurol Neurosurg Psychiatry. 1986 Nov;49(11):1301-4. doi: 10.1136/jnnp.49.11.1301.
2
Regional cerebral blood flow in parkinsonism. Measurement before and after levodopa.帕金森病患者的局部脑血流量。左旋多巴治疗前后的测量。
J Neurol Sci. 1978 Oct;38(3):391-7. doi: 10.1016/0022-510x(78)90144-2.
3
Levodopa challenge neuroimaging of levodopa-related mood fluctuations in Parkinson's disease.帕金森病中左旋多巴相关情绪波动的左旋多巴激发神经成像
Neuropsychopharmacology. 2005 Mar;30(3):590-601. doi: 10.1038/sj.npp.1300632.
4
Long term treatment and disease severity change brain responses to levodopa in Parkinson's disease.长期治疗和疾病严重程度会改变帕金森病患者大脑对左旋多巴的反应。
J Neurol Neurosurg Psychiatry. 2003 Jul;74(7):844-51. doi: 10.1136/jnnp.74.7.844.
5
[The effects of dopamine on regional cerebral blood flow in patients with Parkinson's disease before and after L-dopa--measurement by Xe-enhanced CT].
Rinsho Shinkeigaku. 1994 Nov;34(11):1099-104.
6
Wearing-off fluctuations in Parkinson's disease: contribution of postsynaptic mechanisms.帕金森病中的剂末现象波动：突触后机制的作用
Ann Neurol. 1994 Jul;36(1):27-31. doi: 10.1002/ana.410360108.
7
8
Levodopa-induced regional cerebral blood flow changes in normal volunteers and patients with Parkinson's disease. Lack of correlation with clinical or neuropsychological improvements.左旋多巴对正常志愿者和帕金森病患者局部脑血流的影响。与临床或神经心理学改善无关。
Mov Disord. 1987;2(4):279-89. doi: 10.1002/mds.870020405.
9
Normal activation of the supplementary motor area in patients with Parkinson's disease undergoing long-term treatment with levodopa.长期接受左旋多巴治疗的帕金森病患者辅助运动区的正常激活。
J Neurol Neurosurg Psychiatry. 1994 May;57(5):567-71. doi: 10.1136/jnnp.57.5.567.
10
Regional cerebral blood flow in hemiparkinsonian patients. Emission computerized tomography of inhaled 133Xenon before and after levodopa.偏侧帕金森病患者的局部脑血流。左旋多巴治疗前后吸入133氙的发射型计算机断层扫描。
Acta Neurol Scand. 1985 Apr;71(4):257-66. doi: 10.1111/j.1600-0404.1985.tb03198.x.
引用本文的文献
1
Motor Improvement-Related Regional Cerebral Blood Flow Changes in Parkinson's Disease in Response to Antiparkinsonian Drugs.帕金森病患者对抗帕金森药物反应中与运动改善相关的脑血流区域变化
Parkinsons Dis. 2019 Mar 3;2019:7503230. doi: 10.1155/2019/7503230. eCollection 2019.
2
Coordinate based meta-analysis of motor functional imaging in Parkinson's: disease-specific patterns and modulation by dopamine replacement and deep brain stimulation.基于坐标的帕金森病运动功能成像的荟萃分析：多巴胺替代和深部脑刺激的疾病特异性模式和调节。
Brain Imaging Behav. 2020 Aug;14(4):1263-1280. doi: 10.1007/s11682-019-00061-3.
3
Arterial spin labelling reveals an abnormal cerebral perfusion pattern in Parkinson's disease.动脉自旋标记显示帕金森病患者存在异常的脑灌注模式。
Brain. 2011 Mar;134(Pt 3):845-55. doi: 10.1093/brain/awq377. Epub 2011 Feb 9.
4
PET measurement of dopamine D2 receptor-mediated changes in striatopallidal function.正电子发射断层扫描（PET）测量多巴胺D2受体介导的纹状体苍白球功能变化。
J Neurosci. 1997 May 1;17(9):3168-77. doi: 10.1523/JNEUROSCI.17-09-03168.1997.
5
6-18F-L-dopa imaging of the dopamine neostriatal system in normal and clinically normal MPTP-treated rhesus monkeys.正常及临床正常的MPTP处理恒河猴多巴胺新纹状体系统的6-18F-L-多巴成像
Exp Brain Res. 1989;78(1):69-80. doi: 10.1007/BF00230688.
6
Subcutaneous apomorphine increases regional cerebral blood flow in parkinsonian patients via peripheral mechanisms.皮下注射阿扑吗啡通过外周机制增加帕金森病患者的局部脑血流量。
Br J Clin Pharmacol. 1991 Aug;32(2):229-34. doi: 10.1111/j.1365-2125.1991.tb03886.x.
本文引用的文献
1
Reduction in regional cerebral blood flow during normal aging in man.
Stroke. 1980 Jan-Feb;11(1):31-5. doi: 10.1161/01.str.11.1.31.
2
The "on-off" phenomenon in Parkinson's disease. Relation to levodopa absorption and transport.帕金森病中的“开-关”现象。与左旋多巴吸收和转运的关系。
N Engl J Med. 1984 Feb 23;310(8):483-8. doi: 10.1056/NEJM198402233100802.
3
Apomorphine-induced changes in local cerebral blood flow in normal rats and after lesions of the dopaminergic nigrostriatal bundle.阿扑吗啡对正常大鼠及多巴胺能黑质纹状体束损伤后大鼠局部脑血流的影响。
Brain Res. 1983 Mar 7;262(2):259-65. doi: 10.1016/0006-8993(83)91016-8.
4
Abnormalities of cerebral oxidative metabolism in animal models of Parkinson disease.帕金森病动物模型中的脑氧化代谢异常。
Neurology. 1982 Apr;32(4):382-9. doi: 10.1212/wnl.32.4.382.
5
Is the mesocortical dopaminergic system involved in Parkinson disease?中脑皮质多巴胺能系统与帕金森病有关吗？
Neurology. 1980 Dec;30(12):1326-30. doi: 10.1212/wnl.30.12.1326.
6
Alterations of regional cerebral blood flow and oxygen metabolism in Parkinson's disease.帕金森病中局部脑血流和氧代谢的改变。
Neurology. 1985 Oct;35(10):1399-405. doi: 10.1212/wnl.35.10.1399.
7
The effects of L-DOPA on regional cerebral blood flow and oxygen metabolism in patients with Parkinson's disease.左旋多巴对帕金森病患者局部脑血流和氧代谢的影响。
Brain. 1985 Mar;108 ( Pt 1):171-91. doi: 10.1093/brain/108.1.171.
8
Differential diagnosis between radiation and tumor plexopathy of the pelvis.
Neurology. 1985 Jan;35(1):1-7. doi: 10.1212/wnl.35.1.1.
9
Regional cerebral blood flow estimated by 133-xenon inhalation.通过吸入 133-氙气估计局部脑血流量。
Stroke. 1975 May-Jun;6(3):245-56. doi: 10.1161/01.str.6.3.245.
10
Brain catecholamines and blood flow.脑儿茶酚胺与血流量。
Life Sci. 1975 Feb 15;16(4):475-86.
Zotero 插件