流产布鲁氏菌培养条件对其抗肿瘤特性的影响。
Influence of the culture conditions of Brucella abortus on its antitumor properties.
作者信息
Collet B, Dazord L, Portoukalian J, Sauvager F, Ruffault A, David C
出版信息
Cancer Immunol Immunother. 1983;14(3):207-8. doi: 10.1007/BF00205363.
Abstract
A heat-inactivated rough mutant of B. abortus increased resistance to a transplantable lymphoma when cultured on solid agar (ag) but not when cultured on a fluid medium (fl). The ag organisms were smaller, more toxic and induced more interferon 2 h after injection than fl. They also contained a phospholipid (cardiolipin) absent from fl preparations.
摘要
流产布鲁氏菌的热灭活粗糙突变株在固体琼脂（ag）上培养时，对可移植性淋巴瘤的抵抗力增强，但在液体培养基（fl）上培养时则不然。与fl相比，ag培养的菌株更小、毒性更强，注射后2小时诱导产生的干扰素更多。它们还含有fl制剂中不存在的一种磷脂（心磷脂）。
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本文引用的文献
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[Sensitization of mice to endotoxins by adrenalectomy or by administration of actinomycin D].[通过肾上腺切除术或放线菌素 D 给药使小鼠对内毒素致敏]
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