IgE可溶性免疫复合物对中性粒细胞趋化性的抑制作用。
Suppressive effect of IgE soluble immune complex on neutrophil chemotaxis.
作者信息
Ito S, Shinomiya K, Mikawa H
出版信息
Clin Exp Immunol. 1983 Feb;51(2):407-12.
The effect of IgE soluble immune complex (SIC) and IgG SIC on neutrophil chemotaxis was investigated. Eight types of SIC were prepared from kappa type IgE myeloma protein and IgG myeloma protein: IgE-anti-kappa SIC in IgE excess and in anti-kappa excess, IgE-anti-epsilon SIC in IgE excess and in anti-epsilon excess, IgG-anti-kappa SIC in IgG excess and in anti-kappa excess, IgG-anti-gamma SIC in IgG excess and in anti-gamma excess. Four types of IgE SIC markedly suppressed neutrophil and chemotaxis, but free IgE, free anti-kappa chain antibody, free anti-epsilon chain antibody and IgG SIC had no inhibitory activity. This inhibitory activity of IgE SIC on neutrophil chemotaxis was cell directed and concentration-dependent. IgE immune complex also inhibited neutrophil chemotaxis when immune complex was formed in the neutrophil chemotaxis.
研究了IgE可溶性免疫复合物（SIC）和IgG SIC对中性粒细胞趋化性的影响。由κ型IgE骨髓瘤蛋白和IgG骨髓瘤蛋白制备了8种类型的SIC：IgE过量和抗κ过量时的IgE-抗κ SIC、IgE过量和抗ε过量时的IgE-抗ε SIC、IgG过量和抗κ过量时的IgG-抗κ SIC、IgG过量和抗γ过量时的IgG-抗γ SIC。4种类型的IgE SIC显著抑制中性粒细胞趋化性，但游离IgE、游离抗κ链抗体、游离抗ε链抗体和IgG SIC无抑制活性。IgE SIC对中性粒细胞趋化性的这种抑制活性是细胞定向的且呈浓度依赖性。当在中性粒细胞趋化过程中形成免疫复合物时，IgE免疫复合物也抑制中性粒细胞趋化性。
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