Morgan P F, Lloyd H G, Stone T W
Eur J Pharmacol. 1983 Jan 28;87(1):121-6. doi: 10.1016/0014-2999(83)90057-2.
Uptake of [3H]adenosine into rat cerebral cortex synaptosomes was studied. Hexobendine (10(-5) M) and the benzodiazepine agonists diazepam (10(-5) M) and flurazepam (10(-4) M) significantly inhibited this uptake, but only if the compounds were pre-incubated for 10 min in the case of the benzodiazepines. The benzodiazepine antagonists Ro15-1788 (10(-5) M) and CGS 8216 (10(-5) M) failed to reverse the action of benzodiazepine agonists or hexobendine on [3H]adenosine uptake. The results add weight to the view that inhibition of adenosine uptake processes by benzodiazepines do not contribute to their behavioural effects.
研究了[3H]腺苷进入大鼠大脑皮层突触体的摄取情况。己酮可可碱（10^(-5) M）以及苯二氮䓬类激动剂地西泮（10^(-5) M）和氟西泮（10^(-4) M）显著抑制了这种摄取，但对于苯二氮䓬类药物而言，只有在化合物预孵育10分钟的情况下才会出现这种抑制作用。苯二氮䓬类拮抗剂Ro15 - 1788（10^(-5) M）和CGS 8216（10^(-5) M）未能逆转苯二氮䓬类激动剂或己酮可可碱对[3H]腺苷摄取的作用。这些结果进一步支持了以下观点，即苯二氮䓬类药物对腺苷摄取过程的抑制作用与其行为效应无关。
