Harris J R, Sawicka J, Gelman R, Hellman S
Int J Radiat Oncol Biol Phys. 1983 Mar;9(3):345-9. doi: 10.1016/0360-3016(83)90294-8.
We performed a retrospective review of 137 patients with locally advanced breast cancer, but without distant metastases, who were treated with radical radiation therapy. Ninety percent of patients had an initial complete response to their radiation therapy. The 5 year rates of local tumor control, survival free of distant failure, and overall survival were 54%, 28% and 30%, respectively. Multivariate analysis revealed that the following features were associated with improved local tumor control: clinically negative axillary nodes, excisional biopsy, radiation dose greater than 6000 rad, and the use of adjuvant systemic therapy. Improved freedom from distant relapse was seen in patients with small primaries and non-inflammatory carcinoma, as well as clinically negative axillary nodes, excisional biopsy, radiation dose greater than 6000 rad, and the use of adjuvant systemic therapy. The results suggest that adequate levels of radiation therapy can provide local tumor control in a significant proportion of patients with locally advanced-breast cancer and that adjuvant systemic therapy is useful in improving both local tumor control and freedom from distant relapse in these patients.
我们对137例局部晚期乳腺癌患者进行了回顾性研究，这些患者无远处转移，接受了根治性放射治疗。90%的患者对放射治疗最初有完全反应。局部肿瘤控制、无远处转移失败生存和总生存的5年率分别为54%、28%和30%。多因素分析显示，以下特征与局部肿瘤控制改善相关：临床腋窝淋巴结阴性、切除活检、放射剂量大于6000拉德以及使用辅助全身治疗。在原发性肿瘤较小和非炎性癌患者中，以及临床腋窝淋巴结阴性、切除活检、放射剂量大于6000拉德以及使用辅助全身治疗的患者中，远处复发自由度有所提高。结果表明，足够剂量的放射治疗可在相当比例的局部晚期乳腺癌患者中实现局部肿瘤控制，辅助全身治疗有助于改善这些患者的局部肿瘤控制和远处复发自由度。
