Linnoila M, Erwin C W, Brendle A, Simpson D
J Clin Psychopharmacol. 1983 Apr;3(2):88-96.
Psychomotor effects of diazepam, 5 and 10 mg, were compared to placebo in 30 highly anxious, nonpsychotic outpatients and age and sex-matched healthy volunteers. Diazepam did not reduce anxiety according to psychiatrists' ratings, but 10 mg of diazepam three times a day reduced the scores of the self-rated visual analogue scale for anxiety compared to placebo. Diazepam, 5 mg, was devoid of adverse psychomotor effects, but diazepam, 10 mg, impaired tracking and divided attention task performance in patients and volunteers alike. Plasma, erythrocyte, and saliva diazepam and N-desmethyldiazepam concentrations did not correlate with the impairment of psychomotor skills over time.
在30名高度焦虑的非精神病门诊患者以及年龄和性别匹配的健康志愿者中，比较了5毫克和10毫克地西泮与安慰剂的精神运动效应。根据精神科医生的评分，地西泮并未减轻焦虑，但与安慰剂相比，每日三次服用10毫克地西泮可降低焦虑自评视觉模拟量表的得分。5毫克地西泮没有不良精神运动效应，但10毫克地西泮会损害患者和志愿者的追踪能力以及注意力分配任务表现。血浆、红细胞和唾液中的地西泮及N-去甲基地西泮浓度与精神运动技能随时间的损害并无关联。
