Wolkowitz O M, Tinklenberg J R
Psychopharmacology (Berl). 1985;85(2):221-3. doi: 10.1007/BF00428418.
Ten normal male volunteers were administered oral diazepam (0.25 mg/kg) or placebo followed 45 min later by IV naloxone (1.2 mg) or placebo. Diazepam produced a marked decrement in performance on tests of memory, visual psychomotor skills, reaction time, and time production. Naloxone alone had no effect on these measures and failed to interact with the diazepam. These findings do not support a role of the endogenous opioid system in normal human cognitive processes or in the behavioral effects of diazepam.
十名正常男性志愿者口服地西泮（0.25毫克/千克）或安慰剂，45分钟后静脉注射纳洛酮（1.2毫克）或安慰剂。地西泮在记忆测试、视觉心理运动技能、反应时间和时间生成测试中导致表现显著下降。单独使用纳洛酮对这些指标没有影响，也未与地西泮产生相互作用。这些发现不支持内源性阿片系统在正常人类认知过程或地西泮行为效应中起作用。
