Del Zompo M, Tocco F, Marrosu F, Passino N, Corsini G U
Psychopharmacology (Berl). 1983;79(2-3):209-14. doi: 10.1007/BF00427814.
In order to study the role of dopamine (DA) in the regulation of seizure mechanisms in man, a non-emetic dose of apomorphine, a direct stimulant of DA receptors, was administered to eight patients effected by different types of epilepsy. The EEG changes induced by apomorphine administration in comparison to those elicited by promazine or placebo were evaluated in a double blind cross-over study. Similarly to promazine treatment, apomorphine worsened the EEG recordings of some patients. The apomorphine-induced increase in paroxysmal activity was observed in patients affected by partial epilepsy and was not related to the sleep-inducing properties of the drug. This effect is interpreted as being the result of a stimulation of DA autoreceptors, mediating a decrease of dopaminergic activity in the central nervous system. The use of apomorphine as an EEG activating agent is suggested.
为了研究多巴胺（DA）在人类癫痫发作机制调节中的作用，对8例患有不同类型癫痫的患者给予非催吐剂量的阿扑吗啡（一种DA受体直接激动剂）。在一项双盲交叉研究中，评估了阿扑吗啡给药引起的脑电图（EEG）变化，并与丙嗪或安慰剂引起的变化进行比较。与丙嗪治疗相似，阿扑吗啡使一些患者的EEG记录恶化。在部分癫痫患者中观察到阿扑吗啡引起的阵发性活动增加，且这一效应与药物的助眠特性无关。这种效应被解释为是DA自身受体受到刺激的结果，介导了中枢神经系统中多巴胺能活性的降低。建议将阿扑吗啡用作EEG激活剂。
