Hlinák Z, Madlafousek J, Krejcí I
Psychopharmacology (Berl). 1983;79(2-3):231-5. doi: 10.1007/BF00427818.
Lisuride (12.5, 125, 250, 400, 600, 800 micrograms/kg) injected IP 40 min prior to observation of adult, but sexually inexperienced, male rats (a) caused a dose-dependent increase in motor activity, (b) suppressed rearing completely at doses of 125 micrograms/kg and above, and (c) caused a dose-dependent increase of specific sniffing of the scent traces of an estrous female, the sniffing lasting the whole duration of a 5-min test at 800 micrograms/kg. In the presence of a passively receptive (lordotic) female, the amount of time devoted to sniffing of the scent traces decreased but was still dose-dependent. The males exhibited relatively more precopulatory behaviour towards the female at 400-800 micrograms/kg. The number of males initiating copulatory behaviour was small and comparable with saline-injected controls. When exposed to sexual stimuli from a weakly soliciting (presenting posture) female the number of lisuride-treated males (250 and 400 micrograms/kg doses were used) initiating copulation was higher in comparison with the controls. At the same time the males began to copulate mostly with short latencies and without any precopulatory behaviour towards the female. The lisuride-treated males reached ejaculation after a very small number of intromissions. The effects of lisuride are discussed from the point of view of lowered behavioural thresholds of the males to specific and distinct stimuli.
在观察成年但无性经验的雄性大鼠前40分钟腹腔注射利苏立得（12.5、125、250、400、600、800微克/千克），结果如下：(a) 导致运动活动呈剂量依赖性增加；(b) 在剂量为125微克/千克及以上时完全抑制竖毛行为；(c) 导致对发情雌性气味痕迹的特定嗅闻呈剂量依赖性增加，在800微克/千克时，嗅闻持续整个5分钟测试过程。在有被动接受（脊柱前凸）雌性存在的情况下，用于嗅闻气味痕迹的时间减少，但仍呈剂量依赖性。雄性在400 - 800微克/千克时对雌性表现出相对更多的交配前行为。开始交配行为的雄性数量较少，与注射生理盐水的对照组相当。当暴露于来自轻度求偶（呈现姿势）雌性的性刺激时，与对照组相比，接受利苏立得治疗的雄性（使用250和400微克/千克剂量）开始交配的数量更多。同时，雄性大多在短潜伏期后开始交配，且对雌性没有任何交配前行为。接受利苏立得治疗的雄性在极少的插入次数后即达到射精。从雄性对特定和明显刺激的行为阈值降低的角度讨论了利苏立得的作用。
