Lisuride inhibits temporarily sexual behavior in female rats.

The effect of lisuride (0.1 and 0.2 mg/kg IP) on the sexual behavior was studied in the adult, ovariectomized and chronically estradiol-primed female rats. The behavioral tests were done under dyadic interaction with males 60 min before and 30, 120 and 360 min after lisuride or saline injection. Lisuride induced a prompt, short-termed and dose-dependent loss of the precopulatory patterns (darting, hopping, presenting posture) while the effect on the copulatory (lordosis) behavior was weaker. A partial restoration of the precopulatory behavior was observed in the 120th min, the full restoration of the original precopulatory states was found in the 360th min. The inhibitory effect of lisuride on feminine sexual behavior is in contrast with its facilitatory effect on masculine sexual behavior in rats. The results suggest that the serotonergic system participates in the mediation of both copulatory (receptive) behavior and precopulatory (proceptive) behavioral patterns.