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Differential dose-response effects of dexamphetamine sulphate on hunger, arousal and mood in human volunteers.

作者信息

Silverstone T, Wells B, Trenchard E

出版信息

Psychopharmacology (Berl). 1983;79(2-3):242-5. doi: 10.1007/BF00427820.

DOI:10.1007/BF00427820
PMID:6405435
Abstract

The effect of dexamphetamine (d-Amp) and placebo on visual analogue scale (VAS) ratings of hunger, arousal and mood in nine male volunteers was observed. d-Amp (10 mg) significantly depressed hunger ratings but did not significantly affect arousal and mood ratings. d-Amp (20 mg) had a significant effect on all three ratings. There was a difference in the pattern of dose-response effects. Whereas 20 mg d-Amp produced greater changes than 10 mg in ratings of mood and arousal, there was no significant difference on ratings of hunger. These differences in dose-response relationships may reflect differences in the underlying neurochemical mechanisms mediating the stimulant and anorectic effects of d-Amp.

摘要

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本文引用的文献

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Attenuation of amphetamine anorexia in rats following subchronic treatment with a tricyclic antidepressant.三环类抗抑郁药亚慢性治疗后大鼠苯丙胺性厌食的减轻
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The effect of small and moderate doses of d-amphetamine on hunger, mood, and arousal in man.小剂量和中等剂量的右旋苯丙胺对人体饥饿感、情绪及觉醒的影响。
Psychopharmacology (Berl). 1980;70(1):109-11. doi: 10.1007/BF00432379.
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The effect of the dopamine receptor blocking drug pimozide on the stimulant and anorectic actions of dextroamphetamine in man.多巴胺受体阻断药物匹莫齐特对右苯丙胺在人体中的兴奋和食欲抑制作用的影响。
Neuropharmacology. 1980 Dec;19(12):1235-7. doi: 10.1016/0028-3908(80)90215-4.
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The anorectic effect of dexamphetamine sulphate.硫酸右苯丙胺的食欲抑制作用。
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Experimental effects of amphetamine: a review.安非他明的实验效应：综述
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