Jain S, Kyriakides M, Silverstone T, Turner P
Psychopharmacology (Berl). 1980;70(1):109-11. doi: 10.1007/BF00432379.
In rats, low doses of d-amphetamine (d-amp) increase rather than decrease food intake. A double-blind study was carried out in nine healthy female subjects to compare the effects of a low (1 mg) and a moderate (10 mg) dose of d-amp and placebo on hunger, mood and arousal. Each subject participated in three experimental sessions, 1 week apart, when they received either 1 mg d-amp, 10 mg d-amp or placebo, according to a random double-blind design. Visual analogue rating scales for hunger, mood and arousal were completed prior to drug administration and at 30-min intervals for 4 h. A questionnaire relating to sleep pattern and side effects was completed the morning after each experimental session. d-Amp (10 mg) produced a significant reduction in hunger ratings as compared with placebo at 2 h and 2.5 h after administration, while 1 mg d-amp had no significant effect on hunger. Mood and arousal were only slightly elevated by 10 mg d-amp, and not at all by 1 mg.
在大鼠中，低剂量的右旋苯丙胺（d-amp）会增加而非减少食物摄入量。对9名健康女性受试者进行了一项双盲研究，以比较低剂量（1毫克）和中等剂量（10毫克）的d-amp以及安慰剂对饥饿感、情绪和觉醒的影响。根据随机双盲设计，每位受试者参加三个实验环节，间隔1周，分别接受1毫克d-amp、10毫克d-amp或安慰剂。在给药前以及给药后4小时内每隔30分钟，完成饥饿感、情绪和觉醒的视觉模拟评分量表。在每个实验环节后的早晨，完成一份关于睡眠模式和副作用的问卷。与安慰剂相比，10毫克d-amp在给药后2小时和2.5小时使饥饿评分显著降低，而1毫克d-amp对饥饿感无显著影响。10毫克d-amp仅使情绪和觉醒略有升高，1毫克则完全没有影响。
