Leyman A M, Goddeeris P, Lauwerijns J M, De Loecker W
Recent Results Cancer Res. 1983;84:264-74. doi: 10.1007/978-3-642-81947-6_20.
Mammary carcinomas induced in rats by DMBA were divided into three types: I, hard proliferating tumors; II, tumors presenting from an early stage the first signs of cystic degeneration; III, lactating tumors. In all three types, cortisol reduced the protein content by 26%-30%. The already high tRNA methyltransferase activity in type I increased by 200% after cortisol treatment. Hormonal treatment of type II increased the previously reduced control methyltransferases by 37%. In the type III lactating tumors, the total tRNA methyltransferases were inhibited by 35% after cortisol treatment. The methyltransferases of types I and II were separated chromatographically into seven analogous peaks, while the enzymes from type III presented a modified pattern. In each case, cortisol treatment affected the activities of several methyltransferases simultaneously without obvious specificity.
用二甲基苯蒽（DMBA）诱导大鼠产生的乳腺癌分为三种类型：I型，硬增殖性肿瘤；II型，从早期就出现囊性变迹象的肿瘤；III型，泌乳性肿瘤。在所有这三种类型中，皮质醇使蛋白质含量降低了26% - 30%。I型中本就较高的tRNA甲基转移酶活性在皮质醇处理后增加了200%。对II型进行激素处理使先前降低的对照甲基转移酶增加了37%。在III型泌乳性肿瘤中，皮质醇处理后总tRNA甲基转移酶被抑制了35%。I型和II型的甲基转移酶通过色谱法分离为七个类似的峰，而III型的酶呈现出一种改变的模式。在每种情况下，皮质醇处理同时影响几种甲基转移酶的活性，且无明显特异性。
