Trübestein G
Fortschr Med. 1978 Apr 13;96(14):755-60.
A new method of destroying thrombi in blood vessels by ultrasound and simultaneously removing them is reported. Experiments were performed in 19 dogs with artificial thrombi in the iliac and the femoral arteries and veins. The length of the thrombi ranged from 4 to 5 cm and the age from 12 h to 9 days. The unit used consisted of a generator, a frequency counter, an ultrasonic transducer with the hollow waveguide, and a vacuum pump. For protection of the vessel wall the guide is surrounded by a plastic tube. The ultrasonic frequency is 26.5 kHz, the amplitude 25--30 micrometer. The time needed to destroy the thrombus by ultrasound and suck out the thrombotic material ranged from 2.5 to 5 min. To check side effects, experiments were performed in 48 dogs. No changes resulting from ultrasonic irradiation were seen in the circulating blood or in the microscopic structure of the vessel wall. Ultrasonic thrombolysis was performed in a 42 year old patient with a 2-day-old thrombosis of the femoral artery. After 4.5 minutes of intermittent ultrasonic irradiation the artery was patent.
据报道，有一种通过超声破坏血管内血栓并同时将其清除的新方法。在19只狗的髂动脉、股动脉和静脉中植入人造血栓进行实验。血栓长度为4至5厘米，形成时间为12小时至9天。所用设备包括一台发生器、一个频率计数器、一个带有空心波导管的超声换能器和一台真空泵。为保护血管壁，波导管被一根塑料管环绕。超声频率为26.5千赫，振幅为25至30微米。通过超声破坏血栓并吸出血栓物质所需时间为2.5至5分钟。为检查副作用，在48只狗身上进行了实验。在循环血液或血管壁微观结构中未观察到超声照射引起的变化。对一名患有股动脉血栓形成2天的42岁患者进行了超声溶栓治疗。经过4.5分钟的间歇性超声照射后，动脉恢复通畅。
