Todd M H, Forrest J B, Cragg D B
Am Heart J. 1983 May;105(5):769-76. doi: 10.1016/0002-8703(83)90239-9.
This study reports the effect of pretreatment of rabbits with aspirin and methysergide on pulmonary vascular and other responses to clots introduced into the lobar pulmonary artery. Pretreatment with 250 mg/kg aspirin significantly (p less than 0.01) reduced the pulmonary artery pressure, the heart rate, and the systemic blood pressure changes induced by embolization. Pretreatment with methysergide 3 mg/kg also significantly (p less than 0.005) reduced the pulmonary artery pressure rise but had no effect on heart rate, systemic blood pressure, or ventilation rate. Pretreatment with a combination of aspirin and methysergide produced an additive effect and reduced the pulmonary artery pressure rise at 2 minutes post embolization from 10 +/- 2 mm Hg in control subjects to 1.3 +/- 0.9 mm Hg. There were no significant alterations in heart rate, systemic blood pressure, or ventilation rate following combined treatment. Responses to arachidonic acid and serotonin were virtually abolished by aspirin and methysergide, respectively. These results suggest a positive role for more than one mediator in the response to clot-induced pulmonary embolism.
本研究报告了用阿司匹林和甲基麦角新碱预处理家兔对肺血管以及对注入叶肺动脉的血凝块的其他反应的影响。用250mg/kg阿司匹林预处理可显著（p<0.01）降低栓塞引起的肺动脉压、心率和全身血压变化。用3mg/kg甲基麦角新碱预处理也显著（p<0.005）降低了肺动脉压升高，但对心率、全身血压或通气率没有影响。阿司匹林和甲基麦角新碱联合预处理产生了相加效应，并将栓塞后2分钟时的肺动脉压升高从对照组的10±2mmHg降低至1.3±0.9mmHg。联合治疗后心率、全身血压或通气率没有显著改变。对花生四烯酸和5-羟色胺的反应分别几乎被阿司匹林和甲基麦角新碱消除。这些结果表明，在对血栓诱导的肺栓塞的反应中，不止一种介质起积极作用。
