将促甲状腺激素（TSH）对促甲状腺激素释放激素（TRH）的反应用作自变量。

Use of TSH response to TRH as an independent variable.

作者信息

Loosen P T, Kistler K, Prange A J

出版信息

Am J Psychiatry. 1983 Jun;140(6):700-3. doi: 10.1176/ajp.140.6.700.

DOI:10.1176/ajp.140.6.700

Abstract

The thyrotropin (TSH) response to thyrotropin-releasing hormone (TRH) was assessed in 35 consecutive male admissions. Patients with TSH blunting were identified; they were compared with patients without blunting and with normal subjects. Patients without TSH blunting were normal as regards all endocrine variables. Patients with TSH blunting showed reduced TSH (but normal prolactin) levels before and after TRH administration, although their thyroid hormone levels and cortisol levels were normal. Height, weight, and body surface were unrelated to TSH blunting. The test-retest reliability of a blunted TSH response was acceptable.

摘要

对35例连续入院的男性患者评估了促甲状腺激素（TSH）对促甲状腺激素释放激素（TRH）的反应。识别出TSH反应迟钝的患者；将他们与无反应迟钝的患者及正常受试者进行比较。无TSH反应迟钝的患者在所有内分泌变量方面均正常。TSH反应迟钝的患者在给予TRH前后TSH水平降低（但催乳素水平正常），尽管他们的甲状腺激素水平和皮质醇水平正常。身高、体重和体表面积与TSH反应迟钝无关。TSH反应迟钝的重测信度是可接受的。