Winokur A, Caroff S N, Amsterdam J D, Maislin G
Biol Psychiatry. 1984 May;19(5):695-702.
A diminished thyrotropin (TSH) response to the administration of thyrotropin-releasing hormone (TRH) has been widely reported in depressed patients. Repeated TRH administration at short intervals has been shown to produce a diminished TRH response in healthy subjects. In the present study, TRH (400 micrograms) was administered to ten healthy male subjects at weekly intervals for 4 weeks. The TSH response to TRH diminished steadily from 8.2 +/- 1.3 microU/ml on Trial 1 to 6.3 +/- 0.7 microU/ml on Trial 4 (p less than 0.05). No change in the prolactin response to TRH administration was observed over the four trials. Reduction in the TSH response to TRH was not correlated with basal concentrations of thyroxine, triiodothyronine, or cortisol.
在抑郁症患者中，促甲状腺激素（TSH）对促甲状腺激素释放激素（TRH）给药的反应减弱已被广泛报道。在健康受试者中，短时间间隔重复给予TRH已被证明会产生减弱的TRH反应。在本研究中，每周一次向10名健康男性受试者给予TRH（400微克），持续4周。TSH对TRH的反应从试验1时的8.2±1.3微单位/毫升稳步下降至试验4时的6.3±0.7微单位/毫升（p<0.05）。在四次试验中，未观察到催乳素对TRH给药反应的变化。TSH对TRH反应的降低与甲状腺素、三碘甲状腺原氨酸或皮质醇的基础浓度无关。
