Daggett P R, Wheeler M J, Nabarro J D
Horm Res. 1978;9(3):121-9. doi: 10.1159/000178904.
A microparticulate form of free testosterone was given orally to 6 hypogonadal men. Plasma levels were followed after a 200-mg dose, and a double-peak effect was observed. This suggests that particles of different sizes were absorbed at different rates. The clinical and biochemical effects were observed over a 2-month period, on a dose of 200 mg twice daily, taken in place of the usual androgen replacement. The results indicate that absorption is not sufficiently reliable for routine use. The large doses required to achieve therapeutic levels, make oral administration of free testosterone impractical.
将游离睾酮的微粒形式口服给予6名性腺功能减退男性。给予200毫克剂量后监测血浆水平，观察到双峰效应。这表明不同大小的颗粒以不同速率被吸收。在2个月期间观察临床和生化效应，剂量为每日两次200毫克，取代通常的雄激素替代治疗。结果表明，吸收不够可靠，无法常规使用。达到治疗水平所需的大剂量使得游离睾酮口服给药不切实际。
