Rutberg H, Henriksson K G, Jorfeldt L, Larsson J, Mårtensson J, Schildt B
Br J Anaesth. 1983 May;55(5):461-7. doi: 10.1093/bja/55.5.461.
A patient with fulminant MH is presented. The metabolic changes in muscle tissue, whole blood and plasma are compared with those obtained from the porcine model. The samples were taken 1 h after treatment (including dantrolene sodium) had been commenced. Increased concentrations of lactate, pyruvate and citrate were found in muscle, whereas the concentrations of potassium, free inorganic phosphate and glycogen were reduced. The ATP, ADP and phosphoryl creatine concentrations remained unchanged. In blood, increased concentrations of alanine, lactate and glycerol were observed. An increase in carbon dioxide production was found. These changes are similar to those found in the porcine model.
本文报告了一例暴发性恶性高热（MH）患者。将该患者肌肉组织、全血和血浆中的代谢变化与猪模型中的变化进行了比较。样本在开始治疗（包括使用丹曲林钠）1小时后采集。结果发现，肌肉中乳酸、丙酮酸和柠檬酸的浓度升高，而钾、游离无机磷酸盐和糖原的浓度降低。三磷酸腺苷（ATP）、二磷酸腺苷（ADP）和磷酸肌酸的浓度保持不变。血液中，观察到丙氨酸、乳酸和甘油的浓度升高。二氧化碳生成增加。这些变化与猪模型中的变化相似。
