Moss S, Oster J R, Perez G O, Katz F H, Vaamonde C A
Horm Res. 1978;9(3):130-6. doi: 10.1159/000178905.
The changes in plasma renin activity (PRA) and plasma aldosterone concentration (PA) in response to dietary sodium restriction and upright posture were evaluated in 7 patients with juvenile-type, insulin-dependent, uncomplicated diabetes mellitus and in 5 healthy volunteers. All patients had normal blood pressure, 24-hour urine protein excretion and endogenous creatinine clearance. Renal sodium conservation and concentrating ability were grossly normal and 5 patients so tested, had normal renal acidification. PRA and PA were normal in every subject suggesting that abnormalities of the renin-aldosterone axis are late complications of diabetes mellitus usually associated with hypertension and nephropathy or neuropathy.
对7例青少年型胰岛素依赖型单纯糖尿病患者及5名健康志愿者，评估了饮食钠限制和直立姿势对血浆肾素活性（PRA）及血浆醛固酮浓度（PA）的影响。所有患者血压正常、24小时尿蛋白排泄及内生肌酐清除率正常。肾脏保钠及浓缩能力总体正常，5例接受此项检测的患者肾脏酸化功能正常。每个受试者的PRA和PA均正常，提示肾素-醛固酮轴异常是糖尿病的晚期并发症，通常与高血压、肾病或神经病变相关。
