人绒毛膜促性腺激素对雄性小鼠血清睾酮、双氢睾酮和雄烯二酮水平的影响。

Effects of hCG on serum levels of testosterone, dihydrotestosterone and androstenedione in male mice.

作者信息

Lau I F, Saksena S K, Chang M C

出版信息

Horm Res. 1978;9(3):169-75. doi: 10.1159/000178910.

Abstract

The concentrations of testosterone (T), 5alpha-dihydrotestosterone (5alpha-DHT) and delta4-androstenedione (delta4 A) in the circulating blood were increased by a single subcutaneous injection of 10 IU of hCG in the mouse. The response of androgen synthesis to hCG stimulation was rapid and persisted over a period of 96 h. The increased supply of T to the peripheral organ(s) under the stimulation of hCG might contribute to an increase in circulating 5alpha-DHT. However, the changes in T/5alpha-DHT ratio implies that the stimulation of T and 5alpha-DHT production by hCG were not of the same degree.

摘要

单次皮下注射10国际单位人绒毛膜促性腺激素（hCG）可使小鼠循环血液中睾酮（T）、5α - 双氢睾酮（5α - DHT）和Δ4 - 雄烯二酮（Δ4 A）的浓度升高。雄激素合成对hCG刺激的反应迅速，并持续96小时。在hCG刺激下，外周器官T供应的增加可能导致循环中5α - DHT增加。然而，T/5α - DHT比值的变化表明，hCG对T和5α - DHT产生的刺激程度不同。