Burov Iu V, Vedernikova N N, Borisova I P, Shvachkin Iu P, Smirnova A P
Biull Eksp Biol Med. 1983 May;95(5):42-4.
TRH and its two analogs with modified hormonal activity were examined for the capacity to antagonize acute and chronic effects of ethanol in mice. It has been demonstrated that L-pyroglutamyl-L-seryl-L-leucinamide, an analog of TRH, that does not affect the secretion of TSH and decreases prolactin production has the same capacity as TRH to reduce the time of ethanol narcosis but produces a lesser effect on the ethanol-induced fall of rectal temperature. Both the drugs did not affect the ethanol-altered ability of mice to hold on the rotating bar. Methyl ether of TRH, a hormonally inactive analog, was ineffective as shown by all the tests. Neither TRH nor its analogs changed the development of tolerance to chronic administration of ethanol, recorded by the rotating bar test and rectal temperature drop.
研究了促甲状腺激素释放激素（TRH）及其两种具有改变激素活性的类似物拮抗乙醇对小鼠急性和慢性影响的能力。已证明，TRH的类似物L-焦谷氨酰-L-丝氨酰-L-亮氨酰胺不影响促甲状腺激素（TSH）的分泌且能降低催乳素的产生，它与TRH具有相同的缩短乙醇麻醉时间的能力，但对乙醇引起的直肠温度下降的影响较小。两种药物均不影响乙醇改变小鼠在旋转杆上保持的能力。TRH的无激素活性类似物——TRH甲醚，在所有测试中均无效。TRH及其类似物均未改变通过旋转杆试验和直肠温度下降记录的对慢性给予乙醇的耐受性发展。
