Babichev V N, Samsonova V M, Airapetiants M G, Kolomeĭtseva I A, Shvachkin Iu P
Probl Endokrinol (Mosk). 1981 Jul-Aug;27(4):35-8.
In experiments on rats, thyroliberin (TRH) and its analogue pyroglutamyl-histidyl-prolinamide stimulating effects on the CNS were shown. They produced a decrease in some phases of the sleep duration (particularly, in the deep one) and augmented the awakening period. At the same time, the antagonistic effect of these compounds with respect to nembutal anaesthesia was seen. On the contrary, TRH analogue pyroglutamyl-seryl-glycinamide decreased the awakening time and prolonged some phases of the sleep, not exerting antagonistic action on nembutal toxic effect. Both TRH analogues did not influence TTH secretion.
在对大鼠的实验中，已表明促甲状腺激素释放激素（TRH）及其类似物焦谷氨酰 - 组氨酰 - 脯氨酰胺对中枢神经系统有刺激作用。它们使睡眠时间的某些阶段（特别是深度睡眠阶段）减少，并延长了觉醒期。同时，观察到这些化合物对戊巴比妥麻醉有拮抗作用。相反，TRH类似物焦谷氨酰 - 丝氨酰 - 甘氨酰胺减少了觉醒时间并延长了睡眠的某些阶段，对戊巴比妥的毒性作用未产生拮抗作用。两种TRH类似物均不影响促甲状腺素（TTH）的分泌。
