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1
Evidence for a hypothalamic disturbance in cyclical oedema.周期性水肿中下丘脑功能紊乱的证据。
Br Med J (Clin Res Ed). 1983 May 28;286(6379):1691-3. doi: 10.1136/bmj.286.6379.1691.
2
Ovulation induction with pulsatile gonadotropin-releasing hormone (GnRH) or gonadotropins in a case of hypothalamic amenorrhea and diabetes insipidus.在下丘脑性闭经合并尿崩症的病例中，采用脉冲式促性腺激素释放激素（GnRH）或促性腺激素进行促排卵治疗。
Gynecol Endocrinol. 2001 Dec;15(6):421-5.
3
Hyperprolactinemia in polycystic ovary syndrome.
Fertil Steril. 1984 May;41(5):719-25.
4
Vasoactive intestinal peptide: evidence for a hypothalamic site of action to release growth hormone, luteinizing hormone, and prolactin in conscious ovariectomized rats.血管活性肠肽：在清醒去卵巢大鼠中，下丘脑作为释放生长激素、促黄体生成素和催乳素的作用位点的证据。
Endocrinology. 1979 Jan;104(1):53-7. doi: 10.1210/endo-104-1-53.
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Hypothalamic-pituitary dysfunction in growth hormone-deficient patients with pituitary abnormalities.患有垂体异常的生长激素缺乏患者的下丘脑 - 垂体功能障碍。
J Clin Endocrinol Metab. 1991 Jul;73(1):79-83. doi: 10.1210/jcem-73-1-79.
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Increased prolactin secretion and thyrotrophin response to thyrotrophin releasing hormone in Klinefelter's syndrome.克兰费尔特综合征中催乳素分泌增加及促甲状腺激素对促甲状腺激素释放激素的反应
Andrologia. 1995 Jan-Feb;27(1):41-5.
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Evidence for increased dopaminergic and opioid activity in patients with hypothalamic hypogonadotropic amenorrhea.下丘脑性低促性腺激素性闭经患者多巴胺能和阿片类活性增加的证据。
J Clin Endocrinol Metab. 1980 May;50(5):949-54. doi: 10.1210/jcem-50-5-949.
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Idiopathic sexual precocity in a boy with growth hormone, prolactin and thyrotropin deficiencies.
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Increased prolactin response to thyrotropin-releasing hormone in primary ovarian failure.原发性卵巢功能衰竭患者对促甲状腺激素释放激素的催乳素反应增强。
Obstet Gynecol. 1982 Mar;59(3):280-4.
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Effects of starvation in rats on serum levels of follicle stimulating hormone, luteinizing hormone, thyrotropin, growth hormone and prolactin; response to LH-releasing hormone and thyrotropin-releasing hormone.饥饿对大鼠血清促卵泡激素、黄体生成素、促甲状腺激素、生长激素和催乳素水平的影响；对促黄体激素释放激素和促甲状腺激素释放激素的反应。
Endocrinology. 1977 Feb;100(2):580-7. doi: 10.1210/endo-100-2-580.

本文引用的文献

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[The "natriuretic factor" in patients with idiopathic edema].[特发性水肿患者中的“利钠因子”]
Schweiz Med Wochenschr. 1980 Jul 19;110(29):1107-11.
2
Effect of prolactin administration and suppression on blood pressure and body fluid compartments in the rat.催乳素的给予和抑制对大鼠血压及体液成分的影响。
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Idiopathic edema: role of diuretic abuse.特发性水肿：利尿剂滥用的作用。
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Evidence for the hypothalamic origin of the polycystic ovary syndrome.
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Approach to the patient with "idiopathic edema" or "periodic swelling".“特发性水肿”或“周期性肿胀”患者的诊疗方法。
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Studies of the mechanism of sodium retention in idiopathic edema.特发性水肿中钠潴留机制的研究。
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7
Idiopathic oedema of women. A clinical and investigative study.
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Idiopathic oedema and prolactin.
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Catecholamine excretion in "idiopathic" edema: decreased dopamine excretion, a pathogenic factor?
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10
Idiopathic edema: pathogenesis, clinical features, and treatment.特发性水肿：发病机制、临床特征及治疗
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周期性水肿中下丘脑功能紊乱的证据。

Evidence for a hypothalamic disturbance in cyclical oedema.

作者信息

Young J B, Brownjohn A M, Chapman C, Lee M R

出版信息

Br Med J (Clin Res Ed). 1983 May 28;286(6379):1691-3. doi: 10.1136/bmj.286.6379.1691.

DOI:10.1136/bmj.286.6379.1691
PMID:6405936
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1548182/
Abstract

Fourteen women with cyclical oedema and six healthy female controls were investigated by use of a test in which thyrotrophin releasing hormone and luteinising hormone releasing hormone were given. Significant differences in the responses of prolactin, luteinising hormone, and follicle stimulating hormone were observed in the patients. These findings suggest that there may be a hitherto unrecognised hypothalamic defect in cyclical oedema that may account for some of the previously unexplained clinical features and lead to a more rational therapeutic approach in the management of the disorder.

摘要

对14名患有周期性水肿的女性和6名健康女性对照者进行了一项试验研究，该试验中给予了促甲状腺激素释放激素和促黄体生成素释放激素。观察到患者的催乳素、促黄体生成素和促卵泡激素反应存在显著差异。这些发现表明，周期性水肿中可能存在一种迄今未被认识的下丘脑缺陷，这可能解释了一些以前无法解释的临床特征，并导致对该疾病的管理采取更合理的治疗方法。