Mori Y, Niwa T, Takahashi H, Toyoshi K, Denda A, Takahashi S, Konishi Y
Cancer Lett. 1983 Apr;18(3):271-5. doi: 10.1016/0304-3835(83)90235-5.
The mutagenic activities of N-nitrosobis(2-hydroxypropyl)amine (BHP) and its related compounds were studied in Salmonella typhimurium TA100 and TA98 strains by Ames's liquid incubation assay in the presence or absence of lung and liver S9 of rats treated with polychlorinated biphenyl (PCB). BHP and its related compounds, N-nitroso-(2-hydroxypropyl)(2-oxopropyl)amine (HPOP), N-nitrosobis(2-oxopropyl)amine (BOP), N-nitrosobis(2-acetoxypropyl)amine (BAP), and N-nitroso-2,6-dimethylmorpholine (NDMM) showed negative mutagenicity in the absence of lung and liver S9 in TA100 and TA98 strains while those compounds showed positive in the presence of liver S9 in TA100 strain. HPOP and BOP showed positive mutagenic activity in the presence of lung S9 in TA100 strain. HPOP showed the strongest mutagenic activity in the presence of lung and liver S9.
采用艾姆斯液体培养试验，在存在或不存在经多氯联苯（PCB）处理的大鼠肺和肝S9的情况下，研究了N-亚硝基双（2-羟丙基）胺（BHP）及其相关化合物在鼠伤寒沙门氏菌TA100和TA98菌株中的致突变活性。BHP及其相关化合物，N-亚硝基-（2-羟丙基）（2-氧代丙基）胺（HPOP）、N-亚硝基双（2-氧代丙基）胺（BOP）、N-亚硝基双（2-乙酰氧基丙基）胺（BAP）和N-亚硝基-2,6-二甲基吗啉（NDMM），在TA100和TA98菌株中不存在肺和肝S9时显示出阴性致突变性，而这些化合物在TA100菌株中存在肝S9时显示出阳性。HPOP和BOP在TA100菌株中存在肺S9时显示出阳性致突变活性。HPOP在存在肺和肝S9时显示出最强的致突变活性。
