Yokose Y, Yamamoto K, Nakajima A, Eimoto H, Maruyama H, Mori Y, Konishi Y
Department of Oncological Pathology, Nara Medical University.
Jpn J Cancer Res. 1988 Jun;79(6):698-704. doi: 10.1111/j.1349-7006.1988.tb02225.x.
The carcinogenic effects of a single intraperitoneal injection of N-nitrosobis(2-hydroxypropyl)amine (BHP) or its metabolic relatives, N-nitrosomethyl(2-hydroxypropyl)amine (MHP), N-nitrosobis(2-oxopropyl)amine (BOP), N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine (HPOP) and N-nitroso-2,6-dimethylmorpholine (NDMM), were studied in male Wistar rats. The main target organ of these nitrosamines proved to be the lung, followed by the thyroid. Lung lesions were induced in a dose-dependent manner with total lung tumor incidences reaching 55% to 100%. BHP, MHP, HPOP and NDMM all caused lung carcinomas to develop (22% to 44% incidence), whereas BOP was only associated with adenomas. On the basis of dose administered and incidence of carcinomas, MHP appeared to be the most potent lung carcinogen of the five nitrosamines investigated. Smaller numbers of neoplasms were also induced in the kidney, urinary bladder, esophagus and intestine at differing rates by these nitrosamines.
研究了单次腹腔注射N-亚硝基双（2-羟丙基）胺（BHP）或其代谢相关物N-亚硝基甲基（2-羟丙基）胺（MHP）、N-亚硝基双（2-氧代丙基）胺（BOP）、N-亚硝基（2-羟丙基）（2-氧代丙基）胺（HPOP）和N-亚硝基-2,6-二甲基吗啉（NDMM）对雄性Wistar大鼠的致癌作用。这些亚硝胺的主要靶器官是肺，其次是甲状腺。肺部病变呈剂量依赖性诱导，总肺肿瘤发生率达55%至100%。BHP、MHP、HPOP和NDMM均导致肺癌发生（发生率为22%至44%），而BOP仅与腺瘤有关。根据给药剂量和癌发生率，MHP似乎是所研究的五种亚硝胺中最有效的肺致癌物。这些亚硝胺还以不同的速率在肾脏、膀胱、食管和肠道中诱导出数量较少的肿瘤。
