兔中性粒细胞中钙代谢的刺激依赖性变化。
Stimulus-dependent changes in calcium metabolism in rabbit neutrophils.
作者信息
Molski T F, Naccache P H, Sha'afi R I
出版信息
Cell Calcium. 1983 Feb;4(1):57-68. doi: 10.1016/0143-4160(83)90049-0.
We have found that the changes in calcium metabolism in rabbit neutrophils produced by the chemotactic synthetic peptide f-Met-Leu-Phe are not sensitive to the calcium chelator EGTA. The present results demonstrate unambiguously that the previously described chemotactic factor induced changes in 45Ca fluxes in rabbit neutrophils do indeed reflect intracellular events. The pool of calcium mobilized by f-Met-Leu-Phe and increase in cell associated 45Ca upon stimulation are both insensitive to the presence of EGTA.
我们发现，趋化性合成肽f-Met-Leu-Phe所引起的兔中性粒细胞钙代谢变化对钙螯合剂乙二醇双四乙酸（EGTA）不敏感。目前的结果明确表明，先前描述的趋化因子诱导的兔中性粒细胞45Ca通量变化确实反映了细胞内事件。f-Met-Leu-Phe动员的钙池以及刺激后细胞相关45Ca的增加对EGTA的存在均不敏感。
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