Vande Stouwe R A, Attia A A, Karanas A, Ciavarella D, Grieco M H
Gastroenterology. 1983 Jul;85(1):186-9.
A 44-yr-old woman with non-A, non-B hepatitis developed agranulocytosis and absence of marrow granulocyte precursor cells with only mild involvement of other blood elements. The agranulocytosis was complicated by gram-negative septicemia, successfully treated with antibiotic therapy. Marrow recovery followed 2 wk of supportive therapy. Before reversal of the agranulocytosis, a future bone marrow transplant was a consideration, making the use of therapeutic granulocyte transfusions, with their ability to sensitize the recipient, potentially harmful. Experience in this case indicates that agranulocytosis associated with non-A, non-B hepatitis may be reversible, and supports the use of supportive care including appropriate antibiotics, and if necessary, granulocyte transfusions, pending marrow recovery.
一名44岁患非甲非乙型肝炎的女性发生了粒细胞缺乏症，骨髓粒细胞前体细胞缺失，其他血液成分仅轻度受累。粒细胞缺乏症并发革兰阴性败血症，经抗生素治疗成功治愈。经过2周的支持治疗后骨髓恢复。在粒细胞缺乏症逆转之前，曾考虑过进行未来的骨髓移植，而使用治疗性粒细胞输注可能有害，因为其会使受者致敏。该病例的经验表明，与非甲非乙型肝炎相关的粒细胞缺乏症可能是可逆的，并支持在骨髓恢复之前使用包括适当抗生素在内的支持性护理，必要时使用粒细胞输注。
