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胃肠外脂肪给药对人体肺血管系统的影响。

Influence of parenteral fat administration on the pulmonary vascular system in man.

作者信息

van Deyk K, Hempel V, Münch F, Kopp M, Graf H, Epple E

出版信息

Intensive Care Med. 1983;9(2):73-7. doi: 10.1007/BF01699260.

DOI:10.1007/BF01699260
PMID:6406580
Abstract

In 16 patients with multiple injuries the effect of parenteral administration of a fat emulsion on the pulmonary vascular system has been studied. Using the Hewlett Packard 5600 A Intensive Care System, which allows vital parameters to be sampled at a rate of two values per min, pulmonary artery pressure (PAP) was monitored before, during, and after the administration of Lipofundin S 20% (0.24 g/kg/h). In addition right ventricular stroke work index (RVSWI), alveolar-arterial oxygen difference (A-aDO2) and pulmonary shunt (Qs/Qt) were calculated. The results indicate that there are no changes of the PAP, the RVSWI, and the A-aDO2 during the period of observation.

摘要

对16例多发伤患者研究了胃肠外给予脂肪乳剂对肺血管系统的影响。使用惠普5600 A重症监护系统(该系统允许以每分钟两个值的速率采集重要参数),在静脉输注20% Lipofundin S(0.24 g/kg/h)之前、期间和之后监测肺动脉压(PAP)。此外,还计算了右心室每搏功指数(RVSWI)、肺泡-动脉血氧分压差(A-aDO2)和肺分流(Qs/Qt)。结果表明,在观察期间PAP、RVSWI和A-aDO2均无变化。

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Pulmonary and circulatory effects of fibrinopeptides.纤维蛋白肽对肺和循环系统的影响。
Circ Res. 1967 Oct;21(4):469-85. doi: 10.1161/01.res.21.4.469.
2
Lipid metabolism and trauma. 3. Plasma lipids and lipoproteins in burns.
Acta Med Scand. 1965 Sep;178(3):337-50.
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Quantiative determination of intravascular coagulation in the lungs of experimental animals.
Scand J Haematol. 1969;6(3):205-15. doi: 10.1111/j.1600-0609.1969.tb01827.x.
4
Fat embolism: an aid to diagnosis.
脂肪栓塞:诊断辅助手段。
J Bone Joint Surg Br. 1970 Nov;52(4):732-7.
5
Trauma and intravascular coagulation.创伤与血管内凝血
Acta Pathol Microbiol Scand A. 1970;78(4):491.
6
The importance of intravascular coagulation and inhibition of the fibrinolytic system in experimental fat embolism.血管内凝血及纤维蛋白溶解系统抑制在实验性脂肪栓塞中的重要性。
J Trauma. 1970 Apr;10(4):287-98. doi: 10.1097/00005373-197004000-00002.
7
Circulatory and respiratory effects of induced platelet aggregation. An experimental study in dogs.
Acta Chir Scand Suppl. 1971;420:1-24.
8
Pulmonary microembolism during intramedullary orthopaedic trauma.骨科创伤髓内固定期间的肺微栓塞
Acta Anaesthesiol Scand. 1974;18(2):133-43. doi: 10.1111/j.1399-6576.1974.tb00852.x.
9
Clinical evaluation of a 10 percent intravenous fat emulsion for parenteral nutrition in thermally injured patients.10%静脉脂肪乳剂用于热损伤患者肠外营养的临床评估。
Ann Surg. 1973 Oct;178(4):503-13. doi: 10.1097/00000658-197310000-00013.
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Scand J Clin Lab Invest. 1974 Jun;33(4):361-9.