• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

小鼠肥大细胞瘤细胞中环磷酸腺苷依赖性蛋白激酶的特性

Properties of the cyclic AMP-dependent protein kinases in mouse mastocytoma cells.

作者信息

Smart J, Ralph R

出版信息

Mol Cell Biochem. 1983;50(2):107-13. doi: 10.1007/BF00285637.

DOI:10.1007/BF00285637
PMID:6406828
Abstract

The properties of type I and type II protein kinases in PY815 mouse mastocytoma cells were shown to change following growth inhibition by prostaglandin E1 and 3-isobutyl-1-methylxanthine. These changes included a large reduction in type I protein kinase consistent with a role for this isoenzyme as a positive effector of growth, a decrease in free cyclic AMP binding protein and an increase in type II protein kinase. Some properties of the fully activated isoenzymes are presented that may be important in determining their activity in vivo.

摘要

在PY815小鼠肥大细胞瘤细胞中，I型和II型蛋白激酶的特性在受到前列腺素E1和3 -异丁基-1 -甲基黄嘌呤抑制生长后发生了变化。这些变化包括I型蛋白激酶大幅减少，这与该同工酶作为生长的正向效应物的作用一致，游离环磷酸腺苷结合蛋白减少，以及II型蛋白激酶增加。文中还介绍了完全激活的同工酶的一些特性，这些特性可能对确定它们在体内的活性很重要。

相似文献

1
Properties of the cyclic AMP-dependent protein kinases in mouse mastocytoma cells.小鼠肥大细胞瘤细胞中环磷酸腺苷依赖性蛋白激酶的特性
Mol Cell Biochem. 1983;50(2):107-13. doi: 10.1007/BF00285637.
2
Changes in cyclic AMP-dependent protein kinases during inhibition of mastocytoma cell growth by dibutyryl cyclic AMP.二丁酰环磷腺苷抑制肥大细胞瘤细胞生长过程中环磷腺苷依赖性蛋白激酶的变化
Mol Cell Biochem. 1982 Apr 2;43(3):183-90. doi: 10.1007/BF00223009.
3
Selective hormonal activation of cyclic AMP-dependent protein kinase isoenzymes in normal and malignant osteoblasts.正常和恶性成骨细胞中环磷酸腺苷依赖性蛋白激酶同工酶的选择性激素激活。
J Biol Chem. 1982 Dec 25;257(24):14983-7.
4
Microheterogeneity of adenosine cyclic monophosphate-dependent protein kinases from mouse brain and heart.来自小鼠脑和心脏的环磷酸腺苷依赖性蛋白激酶的微异质性
Biochem J. 1978 Nov 1;175(2):367-75. doi: 10.1042/bj1750367.
5
Cyclic AMP, nuclear protein kinase and the PY815 cell cycle.环磷酸腺苷、核蛋白激酶与PY815细胞周期
Mol Cell Biochem. 1985 May;67(1):31-8. doi: 10.1007/BF00220983.
6
Cell cycle specific fluctuations of adenosine 3',5' -monophosphate and prostaglandin binding in synchronized mastocytoma P-815 cells.
Biochem Pharmacol. 1982 Jan 15;31(2):173-9. doi: 10.1016/0006-2952(82)90207-6.
7
Adenosine 3':5'-cyclic monophosphate-dependence of protein kinase isoenzymes from mouse liver.小鼠肝脏蛋白激酶同工酶对3':5'-环磷酸腺苷的依赖性
Biochem J. 1976 Jul 1;157(1):117-26. doi: 10.1042/bj1570117.
8
Prostaglandin-E2-induced activation of adenosine 3'-5' cyclic monophosphate-dependent protein kinases of a murine macrophage-like cell line (P388D1).前列腺素E2诱导的鼠巨噬细胞样细胞系（P388D1）中3'-5'环磷酸腺苷依赖性蛋白激酶的激活。
J Immunol. 1987 Nov 15;139(10):3416-21.
9
Two forms of ATP sulfurylase in Furth mouse mastocytoma.弗思小鼠肥大细胞瘤中的两种形式的ATP硫酸化酶。
Life Sci II. 1970 Oct 22;9(20):1151-8. doi: 10.1016/0024-3205(70)90033-0.
10
Kinetics of adenosine 3':5'-monophosphate-dependent protein kinase activation and inhibition of thymidine incorporation into DNA in P1798 lymphosarcoma cells.P1798淋巴肉瘤细胞中3':5'-环磷酸腺苷依赖性蛋白激酶激活的动力学及胸苷掺入DNA的抑制作用
Cancer Res. 1983 Aug;43(8):3514-20.

引用本文的文献

1
Cyclic AMP, nuclear protein kinase and the PY815 cell cycle.环磷酸腺苷、核蛋白激酶与PY815细胞周期
Mol Cell Biochem. 1985 May;67(1):31-8. doi: 10.1007/BF00220983.

本文引用的文献

1
Distinct conformational changes in the catalytic subunit of cAMP-dependent protein kinase around physiological conditions. Do these changes reflect an ability to assume different specificities?环磷酸腺苷（cAMP）依赖性蛋白激酶催化亚基在生理条件附近的独特构象变化。这些变化是否反映了其具有不同特异性的能力？
Biochem Biophys Res Commun. 1980 Sep 16;96(1):77-84. doi: 10.1016/0006-291x(80)91183-3.
2
Altered ratios and different subcellular distribution of type I and type II cAMP-dependent protein kinases in several thyroidal pathological tissues.
FEBS Lett. 1981 Mar 23;125(2):155-8. doi: 10.1016/0014-5793(81)80707-7.
3
Effect of sodium n-butyrate on induction of prostaglandin synthase activity in cloned mastocytoma P-815 2-E-6 cells.丁酸钠对克隆的肥大细胞瘤P-815 2-E-6细胞中前列腺素合酶活性诱导的影响。
Biochem J. 1981 Jan 15;194(1):111-7. doi: 10.1042/bj1940111.
4
Involvement of cAMP and cAMP-dependent protein kinase in the initiation of DNA synthesis by rat liver cells.
Exp Cell Res. 1981 Sep;135(1):199-211. doi: 10.1016/0014-4827(81)90312-8.
5
Growth arrest and morphological change of human breast cancer cells by dibutyryl cyclic AMP and L-arginine.二丁酰环磷腺苷和L-精氨酸对人乳腺癌细胞生长的抑制及形态学改变
Science. 1981 Oct 2;214(4516):77-9. doi: 10.1126/science.6269181.
6
The autophosphorylation reaction in the mechanism of activation of pig brain cyclic AMP-dependent protein kinase.猪脑环磷酸腺苷依赖性蛋白激酶激活机制中的自磷酸化反应。
Biochim Biophys Acta. 1981 Jul 24;660(1):110-6. doi: 10.1016/0005-2744(81)90115-7.
7
Degradative inactivation of cyclic AMP-dependent protein kinase by a membranal proteinase is restricted to the free catalytic subunit in its native conformation.一种膜蛋白酶对环磷酸腺苷依赖性蛋白激酶的降解失活作用仅限于其天然构象的游离催化亚基。
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3492-5. doi: 10.1073/pnas.78.6.3492.
8
Effect of adenosine 3',5'-monophosphate on growth and several functions of cultured mastocytoma P-815 cells.
J Pharmacobiodyn. 1980 Mar;3(3):136-48. doi: 10.1248/bpb1978.3.136.
9
Binding proteins for cyclic AMP in mammalian tissues.哺乳动物组织中环磷酸腺苷的结合蛋白。
Int J Biochem. 1981;13(1):1-19. doi: 10.1016/0020-711x(81)90131-2.
10
Characterization of cyclic AMP-resistant Chinese hamster ovary cell mutants lacking type I protein kinase.缺乏I型蛋白激酶的抗环磷酸腺苷中国仓鼠卵巢细胞突变体的特性分析
J Biol Chem. 1981 Jan 25;256(2):926-32.