小鼠免疫球蛋白重链基因的多样性和连接片段紧密相连且方向相同：对连接机制的启示。
Diversity and joining segments of mouse immunoglobulin heavy chain genes are closely linked and in the same orientation: implications for the joining mechanism.
作者信息
Wood C, Tonegawa S
出版信息
Proc Natl Acad Sci U S A. 1983 May;80(10):3030-4. doi: 10.1073/pnas.80.10.3030.
Abstract
We have mapped 12 diversity (D) gene segments of mouse Ig heavy chains between 80 and 1 kilobases 5' to the four joining (JH) gene segments by molecular analysis of DNA clones isolated from recombinant phage and cosmid libraries. All identified D and JH segments are in the same 5'-3' orientation. The significance of these findings with respect to the joining mechanism for Ig gene segments is discussed.
摘要
我们通过对从重组噬菌体和黏粒文库中分离出的DNA克隆进行分子分析，绘制了小鼠Ig重链的12个多样性（D）基因片段的图谱，这些片段位于四个连接（JH）基因片段5'端80至1千碱基之间。所有已鉴定的D和JH片段都呈相同的5'-3'方向。本文讨论了这些发现对于Ig基因片段连接机制的意义。
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