大鼠背侧束损伤未能增加对低强度音调的分心程度。
Failure of dorsal bundle lesions in rats to increase distractibility to a low intensity tone.
作者信息
Dragunow M, Laverty R
出版信息
Pharmacol Biochem Behav. 1983 May;18(5):673-5. doi: 10.1016/0091-3057(83)90004-7.
PMID:6407033
Abstract
Bilateral lesions of the dorsal noradrenergic bundle in rat brains with 6-hydroxydopamine produced a depletion of cortical noradrenaline to 19% of control values. Rats so treated showed resistance to extinction of a lever press task but no increased distractability from licking behaviour by a low intensity tone. These results cast doubt on the hypothesis that dorsal noradrenergic bundle lesions cause hyperdistractibility in rats.
摘要
用6-羟基多巴胺造成大鼠脑内去甲肾上腺素能背束双侧损伤后，皮质去甲肾上腺素含量降至对照值的19%。经如此处理的大鼠在杠杆按压任务的消退方面表现出抗性，但在低强度音调刺激下舔舐行为的分心程度并未增加。这些结果对去甲肾上腺素能背束损伤会导致大鼠过度分心这一假说提出了质疑。
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