Kiianmaa K, Hoffman P L, Tabakoff B
Psychopharmacology (Berl). 1983;79(4):291-4. doi: 10.1007/BF00433403.
The effects of naltrexone on the increase in locomotor activity induced by a low dose (1.35 g/kg IP) of ethanol and on the duration of loss of righting reflex after a high dose (3.5 g/kg) of ethanol were studied in BALB/c, DBA/2, and C57BL/6 mice. Ethanol increased locomotor activity in DBA and BALB mice, but not in C57BL mice. Naltrexone, at a dose of 0.1 mg/kg, antagonized the ethanol-induced increase in locomotion similarly in DBA and BALB mice. The duration of loss of righting reflex was, however, differentially affected in all three strains by naltrexone. The BALB mice affected in all three strains by naltrexone. The BALB mice were the most sensitive strain (1 mg/kg naltrexone significantly counteracted ethanol hypnosis), the C57BL mice were intermediate (8 mg/kg naltrexone required to antagonize this effect of ethanol), and the DBA mice were least sensitive (no effect evident even at the highest dose of 8 mg/kg) to naltrexone. Thus, naltrexone could antagonize the behavioral effects of a low and high dose of ethanol, but the three strains, which differ in their behavioral response to ethanol, also were differentially sensitive to the effect of naltrexone in reversing ethanol-induced hypnosis and ethanol-induced changes in locomotor activity.
在BALB/c、DBA/2和C57BL/6小鼠中研究了纳曲酮对低剂量（1.35 g/kg腹腔注射）乙醇诱导的运动活动增加以及高剂量（3.5 g/kg）乙醇后翻正反射丧失持续时间的影响。乙醇增加了DBA和BALB小鼠的运动活动，但未增加C57BL小鼠的运动活动。剂量为０.1mg/kg的纳曲酮在DBA和BALB小鼠中类似地拮抗了乙醇诱导的运动增加。然而，纳曲酮对所有三个品系翻正反射丧失的持续时间有不同影响。纳曲酮对所有三个品系的BALB小鼠都有影响。BALB小鼠是最敏感的品系（1mg/kg纳曲酮显著对抗乙醇催眠作用），C57BL小鼠为中等敏感（需要8mg/kg纳曲酮才能拮抗乙醇的这种作用），而DBA小鼠对纳曲酮最不敏感（即使在最高剂量8mg/kg时也无明显作用）。因此，纳曲酮可以拮抗低剂量和高剂量乙醇的行为效应，但这三个品系对乙醇的行为反应不同，对纳曲酮逆转乙醇诱导的催眠作用和乙醇诱导的运动活动变化的效应也有不同的敏感性。
