Pimoule C, Briley M S, Gay C, Loo H, Sechter D, Zarifian E, Raisman R, Langer S Z
Psychopharmacology (Berl). 1983;79(4):308-12. doi: 10.1007/BF00433407.
3H-Rauwolscine binds specifically and with high affinity to alpha 2-adrenoceptors in human platelets. In a study comparing the binding of 3H-rauwolscine in platelets obtained from 26 control volunteers with 19 hospitalised, untreated, severely depressed patients, the mean maximal binding (Bmax) and mean dissociation constant (Kd) of 3H-rauwolscine binding were found to be identical in both groups. After 7-12 days, treatment with different tricyclic antidepressant drugs there was a significant improvement in the depressive symptoms but no change in the 3H-rauwolscine binding. After an average of 23 days treatment with tricyclic antidepressants, and when the Hamilton Depression Rating Scores had returned to normal, the Kd and Bmax of 3H-rauwolscine binding were still unchanged.
3H-育亨宾能特异性且高亲和力地与人血小板中的α2-肾上腺素能受体结合。在一项研究中，比较了从26名对照志愿者和19名住院的未经治疗的重度抑郁症患者获得的血小板中3H-育亨宾的结合情况，发现两组中3H-育亨宾结合的平均最大结合量（Bmax）和平均解离常数（Kd）相同。在使用不同的三环类抗抑郁药治疗7 - 12天后，抑郁症状有显著改善，但3H-育亨宾结合情况没有变化。在平均使用三环类抗抑郁药治疗23天后，当汉密尔顿抑郁评分恢复正常时，3H-育亨宾结合的Kd和Bmax仍然没有改变。
