Concepts in the pharmacologic and nonpharmacologic support of cardiovascular function in critically ill surgical patients.

The critically ill surgical patient requires close clinical, biochemical, and hemodynamic monitoring to define the right timing as well as the proper type of therapeutic intervention. Although many factors are available for monitoring, O2 delivery and extraction are two of the most important, since the enhanced metabolic demands of the stressed patient dictate a need to maintain greater than normal values to ensure survival. In other situations, primary therapy of the blood pressure, the PCWP, or other indices may take temporary precedence in the choice of therapeutic agents. Regardless of the means used to optimize O2 delivery, scrutiny of the consequences of therapy is equally important. Above all, any therapeutic intervention does not negate the need to treat the primary underlying process expeditiously.