Oksenberg J, Amar A, Cohen N, Grosse-Wilde H, Cohen I, Sharon R, Nelken D, Brautbar C
Tissue Antigens. 1983 Apr;21(4):271-80.
An homozygous typing cell for a local HLA-D determinant"BG", defined by family study, is described. HLA-D "BG" recognizes a specificity identical to the Japanese HLA-DHO (Dw12). Two families and 102 randomly selected healthy Israeli individuals were typed for the HLA-D "BG" determinant. HLA-D "BG" showed segregation as a single determinant within families. The gene frequency for this allele was 0.045, compared to the frequency of 0.148 for DHO in Japanese. In the Israeli population "BG" is in strong association with HLA-Bw52 (joint occurrence = 7.80%) and DR2 (joint occurrence = 8.80%), resembling the data reported foar DHO (Dw12) in Japan. The frequency of this allele may partially account for the low frequency of HLA-Dw2 in the Israeli population.
本文描述了通过家系研究确定的一种针对当地HLA-D决定簇“BG”的纯合分型细胞。HLA-D“BG”识别出一种与日本HLA-DHO（Dw12）相同的特异性。对两个家系和102名随机选择的以色列健康个体进行了HLA-D“BG”决定簇的分型。HLA-D“BG”在家族中表现为单一决定簇的分离。该等位基因的基因频率为0.045，而日本DHO的频率为0.148。在以色列人群中，“BG”与HLA-Bw52（联合出现率=7.80%）和DR2（联合出现率=8.80%）有很强的关联，这与日本报道的DHO（Dw12）的数据相似。该等位基因的频率可能部分解释了以色列人群中HLA-Dw2频率较低的原因。
