Brockbank K G, van Peer C M
Acta Haematol. 1983;69(6):369-75. doi: 10.1159/000206924.
We have demonstrated that hemopoietic organ fibroblastoid cells can produce colony-stimulating activity (CSA) in vitro. Skin fibroblasts also produced CSA. The colonies which formed were restricted to the granulocyte/macrophage differentiation pathways. A linear relationship was obtained for granulocyte/macrophage colony formation in the presence of a variable number of bone marrow-derived fibroblastoid colonies. Fibroblastoid cells did not produce biologically detectable burst-promoting activity for erythroid progenitors. The importance of these observations with respect to in vitro hemopoietic regulatory phenomena are considered.
我们已经证明，造血器官成纤维样细胞能够在体外产生集落刺激活性（CSA）。皮肤成纤维细胞也能产生CSA。所形成的集落仅限于粒细胞/巨噬细胞分化途径。在存在不同数量的骨髓来源成纤维样集落的情况下，粒细胞/巨噬细胞集落形成呈线性关系。成纤维样细胞对红系祖细胞不产生生物学上可检测到的爆式促进活性。本文考虑了这些观察结果对于体外造血调节现象的重要性。
