Golbus M S
Am J Obstet Gynecol. 1983 Jun 15;146(4):435-8. doi: 10.1016/0002-9378(83)90824-4.
Several potential chromosomal mutagens were employed in an effort to induce mouse oocyte meiotic nondisjunction. Rat follicle-stimulating hormone, clomiphene citrate, and methotrexate each failed to increase the incidence of oocyte metaphase aneuploidy. A "temperature stress" system produced a marked increase in meiotic nondisjunction. Increased maternal age did not cause an increase in susceptibility to this chromosome mutagen model. This suggests that the maternal age relationship to aneuploidy is not likely to be due to an increased sensitivity of oocytes from older females to chromosomal mutagens.
为了诱导小鼠卵母细胞减数分裂不分离，使用了几种潜在的染色体诱变剂。大鼠促卵泡激素、枸橼酸氯米芬和甲氨蝶呤均未能增加卵母细胞中期非整倍体的发生率。一种“温度应激”系统使减数分裂不分离显著增加。母亲年龄的增加并未导致对这种染色体诱变模型的易感性增加。这表明母亲年龄与非整倍体的关系不太可能是由于老年女性的卵母细胞对染色体诱变剂的敏感性增加所致。
