Steinherz P G, Rosen G, Miller D R
Am J Pediatr Hematol Oncol. 1983 Spring;5(1):39-44.
To evaluate the possible additive leukocyte count-enhancing properties of lithium and oxymetholone, patients (1-21 years old) were randomized to receive lithium or lithium plus oxymetholone after chemotherapy. Seventy-one trials with lithium, 63 with both drugs, and 79 in the control group, were compared. White blood cell count and neutrophil nadirs were better in both treatment groups than in the controls (p = 0.001) but an additive effect of oxymetholone above and over lithium alone was seen only in patients under 15 years old (p = 0.05). The median duration of severe neutropenia (absolute neutrophil count less than 1000/cm3) was 6.2 days/patient in the control group but only 4.5 days/patient and 3.8 days/patient in the lithium and lithium plus oxymetholone groups, respectively (p = 0.0001). Both the lithium and lithium plus oxymetholone treatments had a modest platelet-sparing effect (p = 0.03). No difference in the hemoglobin nadirs was observed in the three groups. While the majority of the patients lost weight in the control and lithium-treated group, the patients on oxymetholone gained weight (median 1.25 kg) p = 0.00001. Lithium reduces the period of neutropenia after chemotherapy during which the patients may acquire infection. The addition of oxymetholone does not substantially lessen myelosuppression in most patients but improves the patients' appetite and weight.
为评估锂盐和羟甲烯龙可能的增加白细胞计数的特性，将患者（1至21岁）在化疗后随机分组，分别接受锂盐或锂盐加羟甲烯龙治疗。对71例使用锂盐的试验、63例使用两种药物的试验和79例对照组试验进行了比较。两个治疗组的白细胞计数和中性粒细胞最低点均优于对照组（p = 0.001），但仅在15岁以下患者中观察到羟甲烯龙相对于单独使用锂盐有相加作用（p = 0.05）。对照组严重中性粒细胞减少（绝对中性粒细胞计数低于1000/立方厘米）的中位持续时间为每位患者6.2天，而锂盐组和锂盐加羟甲烯龙组分别为每位患者4.5天和3.8天（p = 0.0001）。锂盐和锂盐加羟甲烯龙治疗均有适度的血小板保护作用（p = 0.03）。三组的血红蛋白最低点无差异。虽然对照组和锂盐治疗组的大多数患者体重减轻，但使用羟甲烯龙的患者体重增加（中位数1.25千克），p = 0.00001。锂盐可缩短化疗后患者可能发生感染的中性粒细胞减少期。添加羟甲烯龙在大多数患者中并未显著减轻骨髓抑制，但可改善患者食欲和体重。
