Pearl R G, Rosenthal M H, Ashton J P
Anesthesiology. 1983 Jun;58(6):514-8. doi: 10.1097/00000542-198306000-00006.
The hemodynamic effects of nitroglycerin (TNG) and sodium nitroprusside (SNP) were studied in a canine model of pulmonary hypertension. Oleic acid administration resulted in pulmonary hypertension with a 133% increase in pulmonary vascular resistance (PVR), a 40% increase in mean pulmonary artery pressure (MPAP), and a 28% decrease in cardiac output (CO). In this model, subsequent TNG administration increased CO 40%, decreased PVR 43%, and decreased MPAP 12%; pulmonary hemodynamics during TNG administration were not significantly different from those prior to oleic acid administration. SNP produced systemic hypotension but did not alter either PVR or MPAP and increased CO only 14%. The efficacy of TNG in this model may relate to its ability to dilate preferentially the pulmonary vascular bed.
在犬类肺动脉高压模型中研究了硝酸甘油（TNG）和硝普钠（SNP）的血流动力学效应。给予油酸导致肺动脉高压，肺血管阻力（PVR）增加133%，平均肺动脉压（MPAP）增加40%，心输出量（CO）减少28%。在该模型中，随后给予TNG使CO增加40%，PVR降低43%，MPAP降低12%；给予TNG期间的肺血流动力学与给予油酸之前相比无显著差异。SNP导致全身低血压，但未改变PVR或MPAP，仅使CO增加14%。TNG在该模型中的疗效可能与其优先扩张肺血管床的能力有关。
