Kerbs S B, Stone J R, Berg S W, Harrison W O
Antimicrob Agents Chemother. 1983 Apr;23(4):541-4. doi: 10.1128/AAC.23.4.541.
Increasing numbers of cases of penicillin-resistant gonorrhea necessitate the evaluation of new antibiotics for treatment of this disease. We tested the susceptibility of 92 penicillinase-producing (PP) Neisseria gonorrhoeae isolates and 88 penicillin-susceptible (PS) isolates to eight new beta-lactam antibiotics. The minimal inhibitory concentrations of these antibiotics were determined by the agar plate method. PP and PS N. gonorrhoeae isolates were susceptible to clinically achievable levels of all antibiotics tested. There were, however, marked differences among the drugs with regard to the concentration required to inhibit growth. The PP N. gonorrhoeae isolates were extremely susceptible to ceftriaxone, ceftizoxime, and cefotaxime, highly susceptible to moxalactam and cefoperazone, and less susceptible to cefoxitin, ceforanide, and cefonicid (geometric mean minimal inhibitory concentrations were 0.002, 0.003, 0.007, 0.03, 0.07, 0.6, 2.4, and 3.1 micrograms/ml, respectively). Although this in vitro study showed PP N. gonorrhoeae isolates to be comparatively more susceptible to ceftriaxone, ceftizoxime, and cefotaxime than to the other antibiotics, these results may not correlate with clinical efficacy.
对青霉素耐药的淋病病例日益增多，因此有必要评估用于治疗该病的新型抗生素。我们检测了92株产青霉素酶（PP）淋病奈瑟菌分离株和88株青霉素敏感（PS）分离株对8种新型β-内酰胺类抗生素的敏感性。这些抗生素的最低抑菌浓度通过琼脂平板法测定。PP和PS淋病奈瑟菌分离株对所测试的所有抗生素在临床可达到的水平上均敏感。然而，不同药物在抑制生长所需浓度方面存在显著差异。PP淋病奈瑟菌分离株对头孢曲松、头孢唑肟和头孢噻肟极度敏感，对拉氧头孢和头孢哌酮高度敏感，而对头孢西丁、头孢尼西和头孢雷特较不敏感（几何平均最低抑菌浓度分别为0.002、0.003、0.007、0.03、0.07、0.6、2.4和3.1微克/毫升）。尽管这项体外研究表明PP淋病奈瑟菌分离株对头孢曲松、头孢唑肟和头孢噻肟相对比对其他抗生素更敏感，但这些结果可能与临床疗效无关。
