新型口服头孢菌素Ro 15-8074对淋病奈瑟菌的体外活性
In vitro activity of Ro 15-8074, a new oral cephalosporin, against Neisseria gonorrhoeae.
作者信息
Ng W S, Chau P Y, Leung Y K, Wong P C
出版信息
Antimicrob Agents Chemother. 1985 Sep;28(3):461-3. doi: 10.1128/AAC.28.3.461.
Abstract
Ro 15-8074, a new cephalosporin the pivaloyloxymethylester of which (Ro 15-8075) is orally absorbable, showed greater in vitro activity than cefaclor against 48 Neisseria gonorrhoeae strains, including 25 penicillinase-producing strains. Unlike cefaclor, Ro 15-8074 was unaffected by increase in inoculum size, and it exhibited a remarkable stability against gonococcal beta-lactamase hydrolysis.
摘要
Ro 15 - 8074是一种新型头孢菌素，其新戊酰氧甲酯（Ro 15 - 8075）可口服吸收。在体外，Ro 15 - 8074对48株淋病奈瑟菌（包括25株产青霉素酶菌株）的活性比头孢克洛更强。与头孢克洛不同，Ro 15 - 8074不受接种量增加的影响，并且对淋球菌β - 内酰胺酶水解表现出显著的稳定性。
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