Barra J A, Villemot J P, Pavie A, Gandjbakhch I, Guiraudon G, Mattei M F, Cabrol C, Cabrol A
Arch Mal Coeur Vaiss. 1983 Feb;76(2):175-82.
Reoperation for secondary deterioration after mitral commissurotomy is associated with a higher immediate postoperative mortality than other open heart operations. We analysed the factors responsible for this increased mortality. A total of 232 patients reported for clinical deterioration after closed heart mitral commissurotomy were reviewed. Mitral valve prostheses were implanted in 202 cases; open heart commissurotomy was possible in 30 cases. Associated procedures included 14 tricuspid valve replacements, 53 tricuspid annuloplasties and 30 aortic valve replacements. The global mortality was 12 p. cent (30 deaths). The causes of death were myocardial failure (19 cases), cerebrovascular accidents (4 cases), prosthetic valve thrombosis (4 cases), infection (2 cases), section of the mitral annulus (1 case). The clinical hemodynamic and anatomical criteria influencing the operative prognosis were analysed: 1. Operative mortality was related to the clinical stage (zero mortality at Stage II, 10,3 p. cent at Stage III, 38 p. cent at Stage IV, p less than 0,001); 2. There was a significant correlation with cardiothoracic ratio: 23 p. cent mortality when greater than 0,60; 9,8 p. cent mortality when less than 0,60 (p less than 0,02); 3. There was a significant correlation with cardiac index: 19 p. cent mortality when less than 21; only 9 p. cent mortality when greater than 21 (p less than 0,04); 4. There was a significant correlation with systolic pulmonary arterial pressure: mortality of 11 p. cent when less than 60 mmHg; mortality of 22 p. cent when greater than 60 mmHg (p less than 0,06). 5. The presence of tricuspid regurgitation increased the operative risk (mortality rose from 12 to 22 p. cent, p less than 0,05) when the surgeon detected moderate or severe tricuspid regurgitation. These results show that the clinical, radiological and hemodynamic aggravation of these patients has a bad influence on operative mortality. This aggravation is not related to the delay between the initial commissurotomy and reoperation but to the delay between the recurrence of symptoms after the first operation and reoperation. Operative mortality was 12 p. cent when this delay was less than 10 years but 23 p. cent when the delay was over 10 years (p less than 0,02). Our findings suggest that these patients should be reoperated earlier if the prognosis of this type of surgery is to be improved.
二尖瓣交界切开术后继发病情恶化而进行再次手术,与其他心脏直视手术相比,术后早期死亡率更高。我们分析了导致死亡率增加的因素。对232例闭式二尖瓣交界切开术后临床病情恶化的患者进行了回顾性研究。202例行二尖瓣瓣膜置换术;30例可行心脏直视交界切开术。相关手术包括14例三尖瓣置换术、53例三尖瓣成形术和30例主动脉瓣置换术。总体死亡率为12%(30例死亡)。死亡原因包括心肌衰竭(19例)、脑血管意外(4例)、人工瓣膜血栓形成(4例)、感染(2例)、二尖瓣环切开(1例)。分析了影响手术预后的临床血流动力学和解剖学标准:1. 手术死亡率与临床分期有关(Ⅱ期死亡率为零,Ⅲ期为10.3%,Ⅳ期为38%,P<0.001);2. 与心胸比率有显著相关性:心胸比率大于0.60时死亡率为23%;小于0.60时死亡率为9.8%(P<0.02);3. 与心脏指数有显著相关性:心脏指数小于2.1时死亡率为19%;大于2.1时仅为9%(P<0.04);4. 与收缩期肺动脉压有显著相关性:收缩期肺动脉压小于60mmHg时死亡率为11%;大于60mmHg时死亡率为22%(P<0.06)。5. 当外科医生检测到中度或重度三尖瓣反流时,三尖瓣反流的存在会增加手术风险(死亡率从12%升至22%,P<0.05)。这些结果表明,这些患者的临床、放射学和血流动力学恶化对手术死亡率有不良影响。这种恶化与初次交界切开术和再次手术之间的间隔时间无关,而是与首次手术后症状复发和再次手术之间的间隔时间有关。当这种间隔时间小于10年时,手术死亡率为12%,但间隔时间超过10年时为23%(P<0.02)。我们的研究结果表明,如果要改善这类手术的预后,这些患者应尽早接受再次手术。