Jones W O, Rothwell T L, Adams D B
Int Arch Allergy Appl Immunol. 1978;57(1):48-56. doi: 10.1159/000232083.
A temporal relationship was established between the onset of expulsion of the parasitic nematode Trichostrongylus colubriformis from the intestine of both vaccinated and adoptively immunized guinea pigs with a sudden increase in small intestinal mucosal histamine to two or three times pre-infection levels. However, in guinea pigs whose capacity to expel T. colubriformis was inhibited by treatment with anti-lymphocyte serum, mucosal histamine remained at pre-infection levels. The results support previous findings which suggest an important role for histamine in the effector mechanism of the immune response of guinea pigs against T. colubriformis.
在接种疫苗和过继免疫的豚鼠肠道中，寄生线虫蛇形毛圆线虫被排出时，小肠黏膜组胺突然增加至感染前水平的两到三倍，由此建立了一种时间关系。然而，在用抗淋巴细胞血清处理后，其排出蛇形毛圆线虫能力受到抑制的豚鼠，黏膜组胺水平维持在感染前水平。这些结果支持了先前的研究发现，即组胺在豚鼠抗蛇形毛圆线虫免疫反应的效应机制中起重要作用。
