Failure to demonstrate involvement of prostaglandins in the immune expulsion of Trichostrongylus colubriformis from the intestine of guinea pigs.

The intraduodenal injection of synthetic prostaglandins did not lead to the expulsion of Trichostrongylus colubriformis from the intestine of guinea pigs. Treatment of immune guinea pigs with aspirin and indomethacin failed to inhibit the expulsion of a challenge infection with this nematode. These results suggest that in this infection, unlike Nippostrongylus brasiliensis infection in the rat, prostaglandins do not play an important role in the immune expulsion of the parasite from the intestine.