Thornton C, Catley D M, Jordan C, Lehane J R, Royston D, Jones J G
Br J Anaesth. 1983 Jun;55(6):479-86. doi: 10.1093/bja/55.6.479.
The effect of increasing end-tidal enflurane concentration on the auditory evoked response was studied in six patients. After a standard induction, anesthesia was maintained with 70% nitrous oxide in oxygen and the end-tidal enflurane concentration was increased gradually from 0 to 1% over a period of 30 min. The averaged auditory evoked response was derived from the electroencephalogram and measurements were made of the latencies and amplitudes of waves I, III, V, Pa and Nb within the auditory evoked response. The latencies of all waves and the interpeak latencies I to V and III to V showed significant linear increases and the amplitudes of Pa and Nb showed significant linear decreases with increasing end-tidal enflurane concentration. These results could not be explained by changes in deep body temperature or end-tidal carbon dioxide concentration. The study demonstrated a dose-related direct effect of enflurane on the brainstem and early cortical components of the auditory evoked response.
在六名患者中研究了增加呼气末安氟醚浓度对听觉诱发电位的影响。在标准诱导后，用70%氧化亚氮和氧气维持麻醉，呼气末安氟醚浓度在30分钟内从0逐渐增加到1%。平均听觉诱发电位由脑电图得出，并对听觉诱发电位中I、III、V、Pa和Nb波的潜伏期和波幅进行测量。随着呼气末安氟醚浓度增加，所有波的潜伏期以及I至V和III至V的峰间潜伏期均呈显著线性增加，Pa和Nb波幅呈显著线性降低。这些结果无法用深部体温或呼气末二氧化碳浓度的变化来解释。该研究证明了安氟醚对听觉诱发电位的脑干和早期皮质成分有剂量相关的直接作用。
