促黄体生成素释放激素类似物治疗高促性腺激素性闭经
Luteinizing hormone releasing hormone analogue in treatment of hypergonadotrophic amenorrhoea.
作者信息
Menon V, Edwards R L, Lynch S S, Butt W R
出版信息
Br J Obstet Gynaecol. 1983 Jun;90(6):539-42. doi: 10.1111/j.1471-0528.1983.tb08964.x.
Abstract
The effect of a luteinizing hormone releasing hormone analogue (HOE 766) was studied in four patients with hypergonadotrophic amenorrhoea (resistant ovary syndrome). After an initial phase of stimulation, there was a uniform and sustained suppression of gonadotrophin concentrations in all the patients during the 20-24 days of treatment, presumably due to down-regulation of the pituitary receptors. One patient ovulated after stopping treatment.
摘要
在四名促性腺激素分泌过多性闭经（抵抗性卵巢综合征）患者中研究了促黄体生成素释放激素类似物（HOE 766）的作用。在初始刺激阶段之后，在治疗的第20 - 24天，所有患者的促性腺激素浓度均出现一致且持续的抑制，这可能是由于垂体受体下调所致。一名患者在停止治疗后排卵。
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