Friedlaender M H, Howes E L, Hall J M, Krasnobrod H, Wormstead M A
Invest Ophthalmol Vis Sci. 1978 Apr;17(4):327-35.
Two distinct patterns of delayed-onset, cell-mediated hypersensitivity have been induced in the guinea pig eye with the same soluble protein antigen and two different methods of immunization. The predominant histologic feature of these reactions was the large number of eosinophils which infiltrated the uveal tract and the limbus. Skin test reactions in the same animals contained very few eosinophils and were typical of cutaneous basophil hypersensitivity or classic delayed hypersensitivity of the tuberculin type. It is suggested that local factors play a role in determining the character of immune expression in different tissues.
用同一种可溶性蛋白抗原和两种不同的免疫方法，在豚鼠眼中诱导出了两种不同类型的迟发型细胞介导超敏反应。这些反应的主要组织学特征是大量嗜酸性粒细胞浸润葡萄膜和角膜缘。同一动物的皮肤试验反应中嗜酸性粒细胞很少，属于皮肤嗜碱性粒细胞超敏反应或结核菌素型经典迟发型超敏反应。提示局部因素在决定不同组织中免疫表达的特征方面起作用。
