Goldman J A
Isr J Med Sci. 1978 Mar;14(3):324-7.
The effect of long-term use of different oral contraceptives compounds was evaluated in two groups of 36 normal women on the basis of blood glucose and plasma insulin changes measured during i.v. glucose tolerance tests. Progestogen (ethynodiol diacetate) alone or a combination-type steroid compound (norethynodrel-mestranol) were used. After 18 months of ethynodiol diacetate therapy, a mild though obvious diabetogenic effect similar to that seen with norethynodrel-mestranol was observed.
在两组各36名正常女性中,根据静脉葡萄糖耐量试验期间测得的血糖和血浆胰岛素变化,评估了长期使用不同口服避孕药化合物的效果。使用了单独的孕激素(双醋炔诺醇)或复合型甾体化合物(异炔诺酮-炔雌醇甲醚)。双醋炔诺醇治疗18个月后,观察到了一种与异炔诺酮-炔雌醇甲醚相似的、轻微但明显的致糖尿病作用。