一种用于π介子治疗束的液体发光组织等效剂量计。

A lyoluminescent tissue-equivalent dosemeter for pion therapy beams.

作者信息

Atari N A, Malik S R, Brenner D J, Hilko R, Bradbury J N

出版信息

Phys Med Biol. 1983 May;28(5):493-502. doi: 10.1088/0031-9155/28/5/004.

Abstract

The light emitted when pion irradiated glucose is dissolved in luminol solution has been found to be proportional to the pion beam depth dose distribution in water as determined by a TE ionisation chamber. The lyoluminescence of glucose overlaps very closely with the response profile of the ionisation chamber to the 170 MeV/c pi--mesons giving a Bragg peak to plateau ratio of 3:1. In comparison, the thermoluminescence response of LiF (TLD-700) to pions has been found to deviate significantly from this ratio. The close tissue equivalence of glucose, non-toxicity and its excellent lyoluminescent retention properties are important advantages over currently used dosemeters in clinical pion therapy, especially when direct in vivo measurements are considered. Pion doses ranging between 0.5 Gy (50 rad) and 30 Gy (3000 rad) were measured with an accuracy +/- 5% and reproducibility 3-5%.

摘要

已发现，π介子辐照葡萄糖后溶解于鲁米诺溶液中所发出的光，与由TE电离室测定的水中π介子束深度剂量分布成正比。葡萄糖的溶解发光与电离室对170 MeV/c π介子的响应曲线非常接近，其布拉格峰与坪区之比为3:1。相比之下，已发现LiF（TLD - 700）对π介子的热释光响应与该比例有显著偏差。葡萄糖与组织的等效性良好、无毒且具有出色的溶解发光保留特性，与临床π介子治疗中目前使用的剂量计相比具有重要优势，尤其是在考虑直接进行体内测量时。测量的π介子剂量范围为0.5 Gy（50 rad）至30 Gy（3000 rad），准确度为±5%，重现性为3 - 5%。